- Birthplace: Mumbai, India
- Awards: Filmfare Award for Best Comedian - 1981, Filmfare Award for Best Performance in a Comic Role
Keshto Mukherjee (Bengali: কেষ্টো মুখোপাধ্যায়; died 1985) was an Indian film actor and comedian. He specialised in comic drunkard roles in the Hindi films. Though he was famous for his drunkard typecast role in Hindi films, he used to share a very good relation with the iconic director Ritwik Ghatak and had very tiny but important roles in the maestro's films such as the trickster in Bari Theke Paliye, the madman in Ajantrik or character roles in Nagarik and Jukti Takko Aar Gappo.